Possible significance of Ph, Zinc and BCR-ABL chimaerism in the pathogenesis of chronic myeloid leukaemia
Identifieur interne : 002D34 ( Main/Exploration ); précédent : 002D33; suivant : 002D35Possible significance of Ph, Zinc and BCR-ABL chimaerism in the pathogenesis of chronic myeloid leukaemia
Auteurs : I. M. Jibrin [Nigeria]Source :
- Medical Hypotheses [ 0306-9877 ] ; 1995.
English descriptors
- Teeft :
- Abnormal, Acrodermatitis enteropathy, Adaptive mechanism, Alkaline phosphatase, Blastic crisis, Blastic transformation, Catalytic function, Cell division, Cell membranes, Cellular proliferation, Chimaeric gene, Chromosome, Chromosome studies, Chronic myeloid leukaemia, Cytogenetic changes, Deficient tissues, Gene chimaerism, Intermediate changes, Isoferritin inhibition, Leukaemia, Leukaemic, Leukaemic cells, Major breakpoint cluster region, Major form, Medical hypotheses, Neutrophil, Normal subjects, Oxford press, Oxford textbook, Pathogenesis, Philadelphia chromosome, Phosphatase, Point mutation, Polymerase, Possible significance, Protein synthesis, Radiation injury, Receptor protein, Regulator unit, Ribonuclease activity, Structural gene, Structural stability.
Abstract
Abstract: Available evidence suggests a double-pathway two-staged genetic alteration in the pathogenesis of Chronic Myeloid Leukaemia (CML). The regular Ph' defect results in BCR-ABL gene chimaerism on the one hand and suppressed synthesis of the protein responsible for Zn absorption on the ether. The resulting Zn deficiency leads, through its metalloenzymes, to a low NAP activity and depressed DNA & RNA polymerase activities: the latter necessitates an adaptive mechanism to sustain cell division despite low zinc. This adaptation is in the form of another gene alteration; a point mutation in the BCR-ABL chimaeric gene, now an oncogene, whose onco-proteins are zinc-independent and stimulate cell division more efficiently (though abnormally also) than the polymerases while defying the usual mechanisms regulating DNA synthesis and cell division. Thus it seems possible that assisted transcellular zinc transport could prevent development of CML in Ph'-positive individuals and the enhanced (abnormal) cellular proliferation might be specifically inhibited.
Url:
DOI: 10.1016/0306-9877(95)90185-X
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002673
- to stream Istex, to step Curation: 002673
- to stream Istex, to step Checkpoint: 001B16
- to stream Main, to step Merge: 002D99
- to stream Main, to step Curation: 002D34
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Possible significance of Ph, Zinc and BCR-ABL chimaerism in the pathogenesis of chronic myeloid leukaemia</title><author><name sortKey="Jibrin, I M" sort="Jibrin, I M" uniqKey="Jibrin I" first="I. M." last="Jibrin">I. M. Jibrin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:30530F776267C10DFAB75CDA63D69B9D5E73D33C</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1016/0306-9877(95)90185-X</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-MC7419SL-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002673</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002673</idno><idno type="wicri:Area/Istex/Curation">002673</idno><idno type="wicri:Area/Istex/Checkpoint">001B16</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001B16</idno><idno type="wicri:doubleKey">0306-9877:1993:Jibrin I:possible:significance:of</idno><idno type="wicri:Area/Main/Merge">002D99</idno><idno type="wicri:Area/Main/Curation">002D34</idno><idno type="wicri:Area/Main/Exploration">002D34</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Possible significance of Ph, Zinc and BCR-ABL chimaerism in the pathogenesis of chronic myeloid leukaemia</title><author><name sortKey="Jibrin, I M" sort="Jibrin, I M" uniqKey="Jibrin I" first="I. M." last="Jibrin">I. M. Jibrin</name><affiliation wicri:level="1"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Nitel Health Centre, Nitel Training School, Cappa - Oshodi, Lagos</wicri:regionArea><wicri:noRegion>Lagos</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Hypotheses</title><title level="j" type="abbrev">YMEHY</title><idno type="ISSN">0306-9877</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">44</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="301">301</biblScope><biblScope unit="page" to="305">305</biblScope></imprint><idno type="ISSN">0306-9877</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-9877</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormal</term><term>Acrodermatitis enteropathy</term><term>Adaptive mechanism</term><term>Alkaline phosphatase</term><term>Blastic crisis</term><term>Blastic transformation</term><term>Catalytic function</term><term>Cell division</term><term>Cell membranes</term><term>Cellular proliferation</term><term>Chimaeric gene</term><term>Chromosome</term><term>Chromosome studies</term><term>Chronic myeloid leukaemia</term><term>Cytogenetic changes</term><term>Deficient tissues</term><term>Gene chimaerism</term><term>Intermediate changes</term><term>Isoferritin inhibition</term><term>Leukaemia</term><term>Leukaemic</term><term>Leukaemic cells</term><term>Major breakpoint cluster region</term><term>Major form</term><term>Medical hypotheses</term><term>Neutrophil</term><term>Normal subjects</term><term>Oxford press</term><term>Oxford textbook</term><term>Pathogenesis</term><term>Philadelphia chromosome</term><term>Phosphatase</term><term>Point mutation</term><term>Polymerase</term><term>Possible significance</term><term>Protein synthesis</term><term>Radiation injury</term><term>Receptor protein</term><term>Regulator unit</term><term>Ribonuclease activity</term><term>Structural gene</term><term>Structural stability</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Available evidence suggests a double-pathway two-staged genetic alteration in the pathogenesis of Chronic Myeloid Leukaemia (CML). The regular Ph' defect results in BCR-ABL gene chimaerism on the one hand and suppressed synthesis of the protein responsible for Zn absorption on the ether. The resulting Zn deficiency leads, through its metalloenzymes, to a low NAP activity and depressed DNA & RNA polymerase activities: the latter necessitates an adaptive mechanism to sustain cell division despite low zinc. This adaptation is in the form of another gene alteration; a point mutation in the BCR-ABL chimaeric gene, now an oncogene, whose onco-proteins are zinc-independent and stimulate cell division more efficiently (though abnormally also) than the polymerases while defying the usual mechanisms regulating DNA synthesis and cell division. Thus it seems possible that assisted transcellular zinc transport could prevent development of CML in Ph'-positive individuals and the enhanced (abnormal) cellular proliferation might be specifically inhibited.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Jibrin, I M" sort="Jibrin, I M" uniqKey="Jibrin I" first="I. M." last="Jibrin">I. M. Jibrin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D34 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D34 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:30530F776267C10DFAB75CDA63D69B9D5E73D33C
|texte= Possible significance of Ph, Zinc and BCR-ABL chimaerism in the pathogenesis of chronic myeloid leukaemia
}}
| This area was generated with Dilib version V0.6.33. |  |